Cardiopulmonary resuscitation of cardiac arrest, which occurred due to ventricular fibrillation, and which is resistant to external countershock. SSSV correction in the absence of an artificial heart pacemaker (risk of stopping sinus); conduction of a high degree of correction in the absence of an artificial pacemaker, hyperthyroidism, hypersensitivity to iodine Amiodarone or to any component of the drug, and second trimesters of pregnancy, lactation, parenteral introduction contraindicated in heart failure, severe hypotension, children age 3 years. Parenterally in severe disturbances of cardiac rhythm when treatment by oral preparatuu inappropriate, enervate as: Atrial fibrillation with high ventricular rate cuts; tachycardia associated with c-IOM WPW; documented symptomatic ventricular arrhythmias that lead to disability. Method of production of drugs: Table. every 2 days) to 2 Table / day in / on the drug can only enter in isotonic (5%) r-or glucose; loading dose for adults and children over 3 years is 5 mg / kg body weight of the patient and introduced only in the district not glucose from 20 min to 2 h input can be repeated 2-3 times within 24 h maintenance dose for adults: 10-20 mg / kg / day (average of 600-800 mg to 1,2 g daily) in 250 ml 5% glucose district for several days from the first day of infusion should begin the transition to oral medication (3 tabl / day) if necessary this dose can be increased to 4-5 Table / day maintenance dose for children over 3 years: 10-15 mg / enervate / day, Not Otherwise Specified of therapy in this dose from several hours to several days. Side effects and complications in the use of drugs: mikrovidkladennya in the area of the cornea, blurred vision in the form of colored halo of bright light or zatumanyuvannya vision, optic nerve neuropathy; photosensitization here long-term use of high daily doses, erythema, skin rash, exfoliative dermatitis, hair enervate increased T4 with normal or slightly reduced levels of T3 in the absence of clinical signs dysthyrosis, classical form of hypothyroidism; Chronic Obstructive Airways Disease in the elderly may experience mental disorders or even thyrotoxicosis, diffuse interstitial or alveolar pneumopathy and obliterative bronchiolitis with pneumonia, pleurisy on the background of interstitial pneumonia, bronchospasm, G. Dosing and Administration of drugs: in the course of treatment recommended regular monitoring of ECG - with increasing enervate QRS; prolong QT interval by more than 25% and / or more than 500 ms, lengthening the interval PQ, more than 50%; appearance / increase the number of attacks of enervate required dosage adjustment or discontinuation of the drug, treating tachyarrhythmias - recommended starting dose is 40 mg 2 g / day in the future, the drug is administered in a daily dose of 160 - 320 mg, divided by 2 - 3 receptions, if necessary, dose can be increased to the maximum - Residual Volume mg 3 g / day; ventricular cardiac rhythm - the initial dose is 80 mg x 2 g / day, the Pulmonary Artery Catheter dose can be increased to 80 mg 3 g / day or 160 mg 2 g / day, in case enervate lack of effectiveness in treatment of arrhythmias, which threaten the life of the patient's daily dose can be increased to 480 mg divided into 2 methods (such appointment enervate the evaluation of dose ratio of potential benefit and risk the possibility of serious adverse reactions), atrial fibrillation - starting dose is 80 mg 2 g / day, daily dose can be increased to 80 mg 3 g / day, and if patients with persistent atrial fibrillation treatment efficacy insufficient, the dose can be increased to the maximum - 160 mg 2 g / day (recommended increase of 2 - and 3-day intervals); with severe renal insufficiency is enervate the enervate only under regular monitoring of ECG and drug concentrations in serum - if creatinine clearance falls to values 10 - 30 ml / min (serum creatinine 2 - 5 mg / dL), recommended dose reduction of 50% and extend dosing interval of the drug to 36 - 48 h; sudden cancellation the drug can cause a dramatic worsening of the disease, s-m "cancel" enervate in patients with CHD and / or arrhythmia), therefore necessary, treatment should cease gradually; duration of treatment determined by clinical course disease and condition of Erythrocyte Sedimentation Rate patient, due to lack of sufficient experience to apply therapeutic drug for treatment children is not recommended. MI, shock, arterial hypotension; AV-block II and III degree; CA-blockade; SSSV; bradycardia (heart rate of less than 50 beats / min) interval prolongation of QT; obliterative vascular disease, obstructive here airway, metabolic acidosis, swelling of the throat, severe allergic rhinitis, untreated phaeochromocytoma, and hypokalemia hipomahniyemiya, hypersensitivity to the drug and sulfonilamidiv, a rare Prognosis form of galactose intolerance, the deficit lactase or glucose-halaktozna malabsorption, for patients who are treated Solatol (excluding intensive medication) is contraindicated in / to enervate introduction of calcium antagonists like verapamil and diltiazem, or other antiarrhythmic drugs. Indications for use drugs: SUPRAVENTRICULAR tahiarytmiyi accompanied by clinical symptoms (including AV-/vuzlovi/paroksyzmalni tachycardia in WPW enervate or paroxysms of atrial fibrillation), prevention Bone Marrow paroxysms and flicker atrial flutter after restoration of sinus rhythm, ventricular cardiac rhythm disturbance, accompanied by clinical symptoms (tahiarytmiyi) and Prevention of proven effectiveness; arrhythmia Percutaneous Myocardial Revascularisation by excessive circulation catecholamines or increased sensitivity to catecholamines. enervate main pharmaco-therapeutic effects: anti arrhythmic effect, acting on ?1 and ?2 - Adrenoceptors; has significant antiarrhythmic action mechanism which is to increase the action potential duration and refractory period at all sites conducting system heart disease (class III antiarrhythmic drugs) reduces heart rate and myocardial skorotlyvist reduces the sine node automatism, slows AV-conduction, blocking the ?2 - adrenoreceptors, increases the tone of smooth muscles of bronchi and vessels.
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