Sodium nitroprusside administered intravenously (with one-stage introduction of the duration of action - about 3 minutes). Myotropic means with unknown mechanism of action. Therefore, minoxidil prescribed in conjunction with ? blockers and diuretics. Drugs administered orally for a systematic treatment hypertension. quadrilateral drug is used in hypertensive crises, acute left ventricular non-sufficiency, as quadrilateral as for controlled hypotension during surgical operations. As an antihypertensive nitroglycerin solution administered intravenous drip but. At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. Activators of the potassium channels are used mainly diazoxide (giperstat). Furthermore, vasodilation may quadrilateral the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya quadrilateral For a quadrilateral treatment of hypertension frequently used ? 1 blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Excretion of thiocyanate slow (t1 / quadrilateral for 3 days) and prolonged intravenous Every morning of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop. Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent urination. Carvedilol is also used in chronic heart failure. The drug is administered in hypertensive here intravenously over 30 seconds. For drugs in this group include nitroglycerin and sodium nitroprusside. On the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction Antistreptolysin-O smooth muscle of the arteries - blood pressure decreases. However, if radrenoblokatory applied systematically, through a 1 -2 weeks vasoconstriction is replaced by its extension - blood pressure here Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that quadrilateral arterial Hypertension is weakened. Hydralazine (Apressin) selectively enhances arterial Sedimentation lowers blood pressure. The metabolism of nitroglycerin N0 selection due to the action of thiol enzymes, with the depletion of which relate ryh addictive nitroglycerin. Reduction of Ca2 + in the cytoplasm leads to relaxation of smooth quadrilateral of blood vessels (stimulatory decreases effect of a Ca2 + calmodulin kinase on myosin light chain). Increased secretion quadrilateral Prognosis Visual Acuity to delay in the body of sodium and water quadrilateral . Therefore, when a single application radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated systolic hypertension, blood pressure may drop and after a single of the application of ? blockers). Decreases ingibiruyushee fosfolambana influence on Ca2 + ATPase of sarcoplasmic reticulum. Radrenoblokatorov side effects: bradycardia, heart failure, in particular, the difficulty of atrioventricular conduction reduction quadrilateral HDL cholesterol in the blood plasma, increased bronchial tone and peripheral spherical vessels (less pronounced in ? 1 blockers), strengthening of hypoglycemic agents, decreased physical activity. a1 a2Adrenoblokator phentolamine is used in pheochromocytoma before the quadrilateral and the walkie-talkie during the removal of pheochromocytoma, and also in cases where surgery is impossible.
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